Children antibiotic-associated diarrhea Research.docVIP

 PAGE \* MERGEFORMAT 19 Children antibiotic-associated diarrhea Research Keywords: children, antibiotic-associated diarrhea Antibiotic-associated diarrhea (antibiotic associated diarrhea, AAD) mainly refers to the use of antibiotics results in intestinal flora disorder caused by diarrhea, including antibiotic itself but also the toxic side effects caused by diarrhea. In recent years, due to widespread use of antibiotics, and even abuse, AAD has increased significantly, while clinicians may easily overlook the problem. Are the nearest 5 years to make a review of the child AAD. An antibiotic-associated diarrhea etiology and pathogenesis of The cause of antibiotic-associated diarrhea and pathogenesis of complex and not yet entirely clear. 1.1 The intestinal flora disturbance At present, most researchers believed that the use of antibiotics undermines the normal intestinal flora, is the most important cause of diarrhea caused. Antibiotics destroy the normal intestinal flora, causing imbalance of intestinal flora. Ⅰ degree disorders are part of antibiotics inhibit or kill bacteria, while another part of the promotion of bacterial growth, which resulted in some parts of the normal flora in the composition and quantity of the abnormal change or shift, in a cause to induce After the swap ratio of reversible to normal; Ⅱ degree of disorder is irreversible imbalance based on the imbalance in the Ⅰ degree fluctuations in bacterial physiology to pathology by the fluctuations; Ⅲ degree of imbalance in the normal performance of the original flora is largely inhibited, and only advantage of the opportunity to become a small number of bacteria the state. , When the number of disorders of intestinal flora probiotics significant drop in the number of abnormal conditions, an increase in pathogenic bacteria, intestinal mucosal barrier injury [1], digestion and absorption of metabolism are affected, resulting in AAD. In conclusion, antibiotics to