Children Henoch-Schonlein purpura nephritis renal expression of VCAM-1 and its significance.docVIP

 PAGE \* MERGEFORMAT 13 Children Henoch-Schonlein purpura nephritis renal expression of VCAM-1 and its significance Of: Li Xiao Lu, Chen Xiaoying, Linrui Xia, Yang Qing, Guang Chen Min [Abstract] Objective: To investigate the purpura nephritis (HSPN) in children with renal biopsy vascular cell adhesion molecule -1 (VCAM-1) expression and its significance. Methods: Immunohistochemical detection of 8 cases and 7 cases of HSPN thin basement membrane disease (control group) obtained by renal biopsy of renal tissue expression of VCAM-1 (with the IOD values #8203;#8203;represent), and renal pathological analysis, the main clinical parameters (including the 24 h urine protein, urine red blood cells) the relationship between . Results: In control group, only a small amount of renal tissue expression of VCAM-1; HSPN children with renal tubular, interstitial, and glomerular expression of VCAM-1 increased to tubulointerstitial sites were significant, and with the ISKDC kidney disease management level increased with the increase; average renal expression of VCAM-1 IOD value of grade - group (6.54 + -2.02) 105, in grade - group (2.45 + -0.07) 105, the control group is (0.76 + -0.12) 105, - grade group and grade - group were significantly higher (all P lt;0.01), and grade - group than in grade - group (P lt; 0.05). HSPN children with renal expression of VCAM-1 IOD value of the classification of its management ISKDC kidney was a significant positive correlation (r = 0.866, P lt;0.01), IgA and C3 deposition volume with no significant correlation (r = 0.339, -0.436, all Pgt; 0.05), and 24 h urinary protein was significantly positively correlated (r = 0.755, P lt;0.05), while the red blood cells and urine sediment showed no significant correlation (r =- 0.626, Pgt; 0.05). CONCLUSION: VCAM-1 involved in the occurrence of HSPN, development process, the renal tissue expression of VCAM-1 may reflect the severity of the disease. [Keywords:] purpura nephritis;