Chronic obstructive pulmonary disease drug therapy.docVIP

 PAGE \* MERGEFORMAT 15 Chronic obstructive pulmonary disease drug therapy [Keywords:] lung disease, drug therapy, progress In pathology, COPD includes chronic bronchitis, bronchiolitis, emphysema, pulmonary vascular disease and systemic complications [1]. COPD is airway macrophages, neutrophils and CD8 + T increased number of cells characterized by a special type of inflammation. For COPD patients, the development of new drugs is very necessary, and many therapeutic targets have been identified. A smoking cessation drugs Present the view that smoking cessation is the only effectively reduce the sexual development of COPD measures. The main problem is that the patient quit smoking nicotine addiction. The most effective smoking cessation treatment is given antidepressant bupropion (bupropion sustained release tablets (SR (Zyban, GlaxoSmithKline [2], in the short 7 weeks after administration, continuous in December to keep stopping smoking rate of 23% [3]. Application of nicotine patches, the 12-month stop smoking rate to 35%. D Dapsone tablets of acetone to 16% COPD smokers quit smoking 4 to 26 weeks continuous [4]. but in the use of bupropion should pay attention to its side effects, bupropion can cause headache, insomnia and mood changes About 0.1% of patients can be epilepsy, more common in those with previous history of epilepsy. The new smoking cessation drug development aid depends largely on the in-depth study of nicotine addiction. At present scholars are studying alternatives to tobacco, said as a “safe cigarette”, this “safe cigarette” that is able to provide odor and low nicotine content of cigarettes, while non-oxidant and tar. This product is of positive significance to help patients quit smoking. Phosphodiesterase 4 inhibitor 2 Phosphodiesterases (PDEs role in modulating cell activity. Enzyme inhibitor can inhibit the inflammatory cells and to smooth muscle relaxation [5]. At present there are 11 family of PDEs, but the most relev