Citreoviridin toxic injury to the heart.docVIP

 PAGE \* MERGEFORMAT 6 Citreoviridin toxic injury to the heart Author: Liu Mi Feng, Wang Lihua, Linlin, Yao Hongju, Zhangfang Ming, Wen-Ge Wang, Yang Jianbo [Abstract] Objective To observe the CIT (CIT) on isolated cardiac cells and myocardial tissue structure and function damage. Method was observed by electron microscopy citreoviridin ultrastructure of myocardial cells in vitro induced by the changes, and 15mg / (kg * d) CIT in rats fed for 8 weeks myocardial tissue pathologic changes were observed. The results of light microscope, CIT treatment groups myocardial degeneration and necrosis occurred, lesions showed foci-like or cord-like distribution, and inflammatory cell infiltration, myofibril aggregation collapse of part of the myocardial cells granular degeneration or degeneration. Electron microscope, 2  5μ mol / L CIT group, irregular cell shape, chromatin margination, muscle wire obvious cytoplasmic particles exist in the lipid droplets, mitochondrial cristae clear, some mitochondria degeneration; 25μ mol / L CIT will enable a complete muscle cell structure disappeared; with the dose increase, increased toxicity. Conclusions CIT in vivo and in vitro may lead to myocardial degeneration and necrosis. [Keywords:] CIT CIT (CIT) is a yellow-green Penicillium sub-toxic metabolites, can be at a lower temperature and higher humidity for the growth 〔 1〕 , widespread in nature, easy to harvest contamination of new crops, was yellow-green mildew , acute poisoning after eating is a human life is closely related to fungal toxins. It has been demonstrated that the toxin has the nerve toxicity and teratogenicity 〔 2〕 〔 3〕 . There are also studies suggest that it may be the cause of Keshan disease 〔 4〕 . The toxin can inhibit in vitro human immunodeficiency virus -1 (HIV-1) activity and the growth of Candida albicans 〔 5〕 . The purpose of this level of observation from the in vivo and in vitro toxic effects of CIT in the heart. 1 Materials and methods 1  1