Climacteric syndrome Progress in Experimental Research.docVIP

 PAGE \* MERGEFORMAT 31 Climacteric syndrome Progress in Experimental Research Authors: Ding-Quan, Cui-lin, Zhang Ruimin Keywords: peri-menopausal period; model; organ index; free radicals; histology Perimenopausal syndrome refers to the women before and after natural menopause or because of ovarian surgery, radiation therapy lead to ovarian failure or loss arising from dysfunction of the autonomic nervous system mainly to a series of clinical symptoms. Experimental and clinical disease have done a lot of depth and detail. Now in recent years, experimental study are summarized below. A model 1.1 The natural aging rats with 3 ~ 6 months of age to adolescence, middle-aged 8 to 12 months of age as a period of 24 months of age for old age after the period from the middle-aged to older pre-transition period for old age. Usually have a choice of 12 ~ 18-month-old female rats as the female climacteric syndrome animal model, because at this stage a large number of reproductive endocrine function decline in performance and Wai menstruating women, menopause is very similar, so the tube can be used natural aging rat model of menopause [1]. 1.2 ovariectomized ovariectomized animal models modeling [2,3] is used in the experiment are more a method, namely: the adult female rats were injected intraperitoneally 2% pentobarbital sodium, anesthesia after removal of both ovaries, routine feeding 20 d, to be fully wound healing Across vaginal smear, a time / d, continuous 5 d, to prove the success of castration. 2 neural   immune system, endocrine The occurrence of climacteric syndrome is due to the decline of ovarian function, leading to nerve   endocrine changes in the immune system, causing a series of clinical syndromes group. In recent years, neuro-endocrine and immune system regulation loop between the doctrine has become a compelling issue. 2.1 Endocrine Xiao Wei [4] the use of home-made Chinese h