Clinical application of mannitol.docVIP

 PAGE \* MERGEFORMAT 7 Clinical application of mannitol [Keywords:] mannitol Mannitol as a traditional dehydrating agent, widely used in clinical, especially in neurology, ophthalmology for the treatment of brain edema and reduce intracranial pressure, intraocular pressure, this retrospective review of ten years of clinical use of mannitol in situation, understand their safety during use, to explore the causes of adverse reactions related factors, provide the basis for the clinical use of drugs. A common adverse reaction of mannitol 1.1 Renal damage is most common in the treatment of cerebral hemorrhage and massive cerebral infarction in patients with hypertension. Such patients with severe illness, mannitol application of large, general 250ml, q6 ~ 8h. Found [1]: kidney damage caused by mannitol was positively correlated with the dose, with the increased use of mannitol accumulated in the body, there will be oliguria, hematuria, proteinuria, renal impairment, BUN, CR increased the daily dose of mannitol is generally believed to be lt;200g, in with poor renal function in old daily dose should be lt;150g appropriate, renal failure, the daily dose of mannitol were generally no more than 50g. In addition to dose-related, the mannitol-induced renal damage with age, underlying diseases, kidney functional status and concomitant medications and other factors, such as the use of mannitol in patients with cerebrovascular disease treatment, and systemic hypertension because of its pathological basis of atherosclerosis itself has the potential impairment of renal function, has resulted in kidney failure due to kidney development in children mature, low renal reserve capacity also cause renal damage. For mild symptoms, no severe headache, vomiting, particularly lacunar infarction patients can temporarily use half the amount or mannitol. dehydrating agent for general use (7 + -3 days, or (14 + -3 days. For the basal ganglia, lobar hemorrhage in 20 ~ 30ml, thalam