Clinical characteristics of pemphigoid target antigen and its Study on the relationship between.docVIP

 PAGE \* MERGEFORMAT 16 Clinical characteristics of pemphigoid target antigen and its Study on the relationship between Authors: Jin Yan 1, HUANG Yi-an, Cheng Yang 2, pay the Navy 3 Abstract of the 56 cases of Jiangsu, Zhejiang regions pemphigoid patients with clinical characteristics and the relationship between the different target antigens were discussed and found pemphigoid, mainly in the elderly, and to bullous more common; in the acute BP phase antibody-binding 230kD, 230/180kD, combined strip target antigens appear more frequently (86.11%); while in disease remission 180kD antigen-antibody binding occurs more frequently (65%); 180kD antigen target antigen is not a minor. Keywords: pemphigoid; clinical features; target antigens 【Abstract】 56 cases of bullous pemphigoid (BP) were studied on the clinical characters and immunol-blot patterns.It was found that bullous pemphigoid happened mostly among old people in bullous type; Autoantigen BP230, BP230/180 and BP 230/180 combined with minor antigens involved in acute phase of BP patient; While BP180 involved mainly in the remission of the disease.Autoantigen BP180 were not minor antigen. 【Keywords:】 bullous pemphigoid; clinical characters; autoantigen Bullous pemphigoid (BP) occurred in the elderly is an autoimmune bullous disease, clinical manifestations of systemic generalized, bullous tension, Niger’s sign negative, repeated protracted course of disease, a serious threat to patients the life and health. BP serum in a variety of different components of anti-skin basement membrane antibodies, with a molecular weight of the target antigen 230kD, 200kD, 180kD, 140kD, 100kD and so on, in order to further explore the clinical features of BP and its target antigen relationship, we intend to collect clinical 56 cases and the results of Western blot synthesis. 1 Materials and 1.1 Clinical data 1.1.1 Object Selection in December 1999 ~ Decem