Coronary heart disease in Xinjiang Uygur and Kazak tumor necrosis factor receptor 2 gene polymorphism.docVIP

 PAGE \* MERGEFORMAT 11 Coronary heart disease in Xinjiang Uygur and Kazak tumor necrosis factor receptor 2 gene polymorphism Of: Xu Guofeng Zhang Jun Wang Qun Li Yong Luo Guanghua Lu Zheng [Abstract] Objective: To study the Uygur and Kazak human tumor necrosis factor receptor 2 (tumor necrosis factor receptor 2, TNFR2 exon 6 196 polymorphism and coronary heart disease. Methods: A case control study The method, ShineRoar probe technology 117 patients with coronary heart disease (including 89 Uighurs, Kazakhs were 28 and 106 healthy subjects (51 of which the Uighurs, Kazakhs were 55 of TNFR2 exon 6 of 196 locus genotypes. Results: Coronary Heart Disease in the general population Uygur TNFR2 exon 6 of 196 point difference in allele and genotype frequencies was not statistically significant, Kazakh TNFR2 exon 6 196 points G allele carriers of the risk of coronary heart disease was significantly higher than T allele carriers (OR = 3.560, 95% CI: 1.157 ~ 8.139, 2 = 9.73, P = 0.002, TG or GG genotype occurred crown the risk of heart disease was significantly higher than the TT genotype. two categories Logistic regression analysis showed that the same gender and age in the control situation, Kazakh TNFR2 exon 6 G allele was significantly associated with coronary heart disease (OR = 4.100, 95% CI: 1.315 ~ 12.780, 2 = 5.916, P = 0.015. Conclusion: Kazakh TNFR2 exon 6 G allele is the major risk factor for coronary heart disease is one. [Keywords:] coronary heart disease, tumor necrosis factor receptor 2 gene polymorphism [Abstract] Objective: To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor receptor 2 (TNFR2) gene and with coronary artery disease (CAD). Methods: A prospective case control study was designed in this investigation. One hundred and seventeen patients (89 were Uighur and 28 from Kazakh) with CAD were compared to with 106 health examination volunteers (51 were Uighur and 55 from Kazakh). Genotyp