Coronary pharmacodynamics of Danshen Injection.docVIP

 PAGE \* MERGEFORMAT 15 Coronary pharmacodynamics of Danshen Injection [Abstract] Objective To observe the coronary Danshen injection on healthy adult SD rats with myocardial ischemia and reperfusion injury in rats. Methods SD rats with coronary ligation and reperfusion 90 min 30 min of myocardial ischemia reperfusion injury model, by hemodynamic, biochemical and histological indicators, evaluation of ischemia-reperfusion pretreatment before coronary Danshen Tablet on left ventricular systolic pressure (LVSP), left ventricular developed pressure (LVDP), left ventricular end diastolic pressure (LVEDP ), left ventricular isovolumic maximum rate of change of pressure (+ -dp/dtmax) and other indexes, by measuring the blood reperfusion after 90 min of lactate dehydrogenase (LDH), creatine kinase (CK) activity and myocardial pathology observed cardioprotective effects of drug evaluation. The results showed that Danshen injection coronary ischemia and reperfusion can improve cardiac function of reduced comfort, lower end of ischemia and reperfusion LDH and CK activity in blood, histopathological examination showed that the : compared with the control group, coronary Danshen injection pretreatment could significantly reduce myocardial tissue damage. Conclusion Danshen injection of anti coronary ischemia-reperfusion induced myocardial injury. [Keywords:] coronary injection, myocardial protection, ischemia-reperfusion Abstract: Objective To observe the cardioprotective effects of Guanxin Danshen injection on myocardium injury induced by ischemia reperfusion in anesthetized adult SD rats. Methods The myocardial injury of rats induced by ischemia-reperfusion was produced by the ligation of left coronary artery for 30 min followed by 90 min reperfusion. The influence of Guanxin Danshen injection on the changes of biochemistry, histology and hemodynamics, such as LVSP, LVDP, LVEDP and dp / dtmax, were evaluated. The serum lactate dehydrogenase (LDH) and creatine