Creactive protein gene promoter T757C polymorphism and the relationship between unstable angina pectoris.docVIP

 PAGE \* MERGEFORMAT 12 Creactive protein gene promoter T757C polymorphism and the relationship between unstable angina pectoris Of: Qi Meng, Guo-Ping, Gao Lei, Shen Dandan, Jinming Feng, Zhang Ji-Nan [Abstract] Objective: To explore the Chinese Han population in Jiangsu and Anhui C-reactive protein (C reaction protein, CRP gene promoter T 757C polymorphism and unstable angina (unstable angina pectoris, UAP possible. Methods: A case control study to 165 patients with UAP patients (case group and 282 patients without coronary heart disease (control group) as a study by polymerase chain reaction - restriction fragment length polymorphism (polymerase chain reaction restriction fragment length polymorphism, PCR RFLP was used to detect CRP gene T 757C polymorphism. Results: Compared with the control group, UAP group, TT, TC and CC genotype had no statistical significance (P valuesgt; 0.05. T allele frequency in the UAP and control groups were 77.6% and 79.1%, no significant difference between the two groups (Pgt; 0.05. Multiple Logistic regression analysis showed that CRP gene T 757C polymorphism and the occurrence of UAP was no significant association (Pgt; 0.05. Conclusion: The Han population in Jiangsu and Anhui in China, CRP gene promoter T 757C polymorphism and UAP was no significant correlation. [Keywords:] C-reactive protein, gene polymorphism, unstable angina [Abstract] Objective: To investigate the possible association between C reaction protein (CRP) gene T 757C polymorphism in the promoter region and unstable angina pectoris (UAP) in a Chinese Han population of Suwan region. Methods: This study was conducted with a case control design including 165 patients with UAP (UAP group) and 282 control subjects who were free from coronary artery disease (control group). The T 757C polymorphism in CRP gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Compared with the control group, the freq