CSDP anti-platelet activation and aggregation of research.docVIP

 PAGE \* MERGEFORMAT 14 CSDP anti-platelet activation and aggregation of research Author: ZHU-ray Luorui Zhi Guo Zhi Xin [Abstract] an overview of CSDP of anti-platelet activation and aggregation of pharmacological and clinical research progress, from the pharmacological point of view of the CSDP of anti-platelet activation and aggregation may be a mechanism by analyzing the preliminary conclusion, CSDP is a multi-site, multi-faceted and multi-target to inhibit platelet activation and aggregation. [Keywords:] CSDP; platelet activation In recent years, the pathophysiology of acute coronary syndrome, mechanisms have been clear trend, mainly atherosclerotic plaque rupture or erosion leading to platelet activation, thrombosis, causing partial obstruction or complete occlusion of coronary arteries, associated with or without a remote micro - circulatory disturbance. Particular concern to scholars of the platelet. CSDP from animal research to clinical observations in recent decades, has been confirmed that there is a definite inhibitory effect on platelet activation and found that its role in inhibiting platelet activation also show multi-site, multi-link, multi-target, multi-level The effect (Figure 1). CSDP has a therapeutic effect in addition to coronary heart disease, helps prevent atherosclerosis and reduce the formation of coronary heart disease in patients with sudden cardio-cerebral vascular accident. Figure 1 CSDP anti-platelet activation and aggregation role in rendering a variety of active ingredients, multi-site, multi-channel, multi-target cells, multi-level effects (abbreviated) A CSDP platelet aggregation pharmacological research Li Jie et al [1] The 72 male SD rats were causing hyperlipidemia model to observe the CSDP 50 mg / kg, 150 mg / kg and 450 mg / kg the efficacy of different doses in order to alginic sodium 25 mg / kg for the control group, gavage, after 13 d were measured indicators of thrombosis in experimental animals, high shear