Cyclovirobuxine D transdermal effect of myocardial ischemia.docVIP

 PAGE \* MERGEFORMAT 15 Cyclovirobuxine D transdermal effect of myocardial ischemia Of: DIANLI, Zhou Liling, Guo Lirong, Lai Xuan City [Abstract] Objective Cyclovirobuxine D (CVB-D) transdermal patch on the experimental model of myocardial ischemia in rabbits. Methods prepared by ligation of the left L-branch animal model of myocardial ischemia, the 15 New Zealand rabbits were randomly divided into 3 groups, the model was the control, were investigated CVB-D patch group and CVB-D oral administration group, the test animals, ECG, plasma lactate dehydrogenase (LDH), creatine kinase (CK) activity, malondialdehyde (MDA) content, and location of myocardial ischemia and wall lining for pathological examination. the results of model group ECG T wave elevation, ST segment deviation significantly, plasma LDH, CK activity and MDA content significantly higher (P lt;0.01), necrotic myocardial cells showed nuclear condensation and nuclear dissolution, collapse of fine granular cytoplasm. patch treatment group and the oral administration group could significantly inhibit the plasma LDH, CK activity and MDA content increased (P lt;0.05), patch treatment group within 32 h in the pharmacodynamic effect is relatively stable, but there is no significant difference between oral group (Pgt; 0.05). Conclusions of CVB-D transdermal patch New Zealand has a myocardial protective effect of ischemic injury. [Keywords:] Cyclovirobuxine D; transdermal patch; myocardial ischemia; pharmacodynamics Abstract: ObjectiveTo explore the pharmacological actions of Cyclovirobuxine D (CVB-D) transdermal patch in rabbit models with myocardial ischemia.MethodsThe animal model with myocardial ischemia was prepared by ligating the left branch of cornary artery of L-branch.15 New Zealand albino rabbits were randomly divided into 3 groups: CVB-D patch group, oral CVB-D group and model group. Electrocardiogram, activities of plasma lactic dehydrogenase (LDH), creatine kinase (CK) and the malondi