Cynoglossum Species Research.docVIP

 PAGE \* MERGEFORMAT 10 Cynoglossum Species Research [Abstract] Boraginaceae Cynoglossum genus of plants, there are about 60 species throughout the world, China has 10 species, 2 varieties. This paper reviews the genus Cynoglossum chemical composition, pharmacological activity and toxicological effect and the application of its further development and research to provide reference. [Keywords:] Cynoglossum genus; chemical composition; pharmacological activity; toxicological effect; Application Boraginaceae Cynoglossum genus Cynoglossum plants around the world there are about 60 species widely distributed in the world, China has 10 species, 2 varieties, are found in other provinces and regions, the southwest region is the distribution center, the main produced in Yunnan, Sichuan and Tibet. The majority of medicinal species, its cold, slightly bitter flavor, with heat-clearing and detoxifying, diuretic swelling, promoting blood circulation to regulate menstruation and other effects. Oral clinical indications of acute nephritis in use, periodontitis, hepatitis, irregular menstruation, leucorrhea abnormalities, edema, jaw acute lymphadenitis and angina pectoris; topical treatment of sore furuncle carbuncle swollen, snake bites, and bruises, etc., all have good efficacy [1]. However, containing some of the pyrrolizidine alkaloids (PAs) with the toxicological effects such as liver toxicity, limiting their practical application. In order to further species of Cynoglossum comprehensive research and development and utilization, the author of the genus Cynoglossum chemical composition, pharmacological activity and toxicological effect and its application are reviewed. A chemical composition 1.1 Alkaloids Alkaloids are the main component of this genus has a wide range of pharmacological and toxicological activity, such as anti-tumor, anti-bacterial, inhibit microbial and liver toxicity. At present, from the type alkaloid found in mainly in PAs, on the basic structure