Dauricine phenolic alkaloids on BXPC3 and the antitumor effect in nude mice the expression of VEGF.docVIP

 PAGE \* MERGEFORMAT 12 Dauricine phenolic alkaloids on BXPC3 and the antitumor effect in nude mice the expression of VEGF Of: Suyun Ming, Li Weijie, Li Yi Hang, Liu Kun, Meng Dan, Zhang Yan, CUI [Abstract] Objective To study the alkaline phenolic bat Ge (PAMD) on BXPC 3 tumor in nude mice and the antitumor effect of new vascular endothelial growth factor (VEGF) expression and further explore its mechanism. Methods BXPC 3 nude animals model to examine the bat Ge phenolic base rate of tumor metastases, using immunohistochemistry to detect the BXPC 3 VEGF expression in tumor tissue in mice. Results dauricine phenolic alkaloids on BXPC 3 pancreatic tumor in nude mice a certain extent, compared with the model group were significant (P lt;0.01). PAMD could significantly reduce the dose BXPC 3 pancreatic tumor in nude mice the expression of VEGF. Conclusion dauricine phenolic alkaloids on BXPC 3 significantly inhibited pancreatic cancer in nude mice. Its mechanism may be nude by improving immune function, inhibit tumor angiogenesis to achieve. [Keywords:] Bat Ge phenolic base; VEGF; immunohistochemistry; BXPC 3 [Abstract] Objective To explore the effects of phenolic alkaloids from menispermum dauricum (PAMD) on tumor inhibitory and expression of basic fibroblast growth factor (VEGF) in BXPC 3 nude mice and to further investigate its protective mechanism for pancreatic carcinoma.Methods The metastatic tumor model of nude mice was established with BXPC 3 cell line.After PAMD treatment, the inhibition rate of tumor proliferation was detected and immunohistochemistry was carried out to confirm the expression of VEGF in nude mice.Results PAMD could inhibit the tumor growth of tumor bearing mice of BXPC 3 cell line (P lt;0.01, vs control group). Meanwhile, PAMD of different doses could inhibit the expression of VEGF in tumor tissue of nude mice.Conclusion PAMD shows conspicuous inhibitory action on the tumor growth of nude mice, which possibly due to its potenc