Destruction of microbubble ultrasound treatment of cancer Research.docVIP

 PAGE \* MERGEFORMAT 14 Destruction of microbubble ultrasound treatment of cancer Research [Abstract] ultrasound contrast agent is a new type of gene transfer and transfection vectors, genes or drug targeting is expected to become an efficient treatment of cancer-specific vector. This article triggered microbubble ultrasound enhanced gene or drug destruction mechanism and transfection its role in the anti-tumor were reviewed in [Keywords:] Ultrasound; microbubbles; permeability; cancer therapy Ultrasound contrast agent in cancer gene therapy, especially in the gene transfer has played an increasingly important role. Ultrasound destruction of microbubbles (ultrasound targeted microbubble destruction, UTMD) can have a therapeutic effect targeted delivery of genes or drugs to increase their dose in the local tumor and reduce systemic side effects. Recent studies show that: load gene microbubbles trigger ultrasonic radiation, through the destruction of microbubbles enhance the permeability of capillary wall and cell membrane so that microbubbles have a more Targeting the high transmission efficiency, thereby increasing gene transfection efficiency to achieve the effect of targeted cancer therapy. This article triggered microbubble ultrasound-mediated destruction of transfected genes or drugs for cancer treatment mechanism and Research reviewed . 1 UTMD enhance the mechanism of gene transfer Ultrasound can promote the gene itself, and UTMD foreign gene is overcome by promoting endometrial cell membrane permeability barriers and enhance the gene expression efficiency. 1.1 The effect of ultrasonic cavitation Ultrasonic cavitation is an effective way to gather energy, it has the low-energy ultrasonic field inside the bubble density is transformed into and around the high energy density characteristics, energy is gathered to a very small volume, the bubble burst and The role of vibration caused when the body produces severe, cell and microbial damag