Diabetic gastroparesis Medicine Research.docVIP

 PAGE \* MERGEFORMAT 22 Diabetic gastroparesis Medicine Research [Keywords:] Diabetes mellitus; gastroparesis; Chinese and Western medicine Diabetic gastroparesis (diabetic gastroparesis, DGP) is associated with diabetes, non-existence of mechanical intestinal obstruction with gastric motility disorders, and emptying delay, main clinical manifestations were nausea, early satiety, postprandial abdominal distension, sodium reduction, vomiting, symptoms such as abdominal pain and weight loss [1]. DGP incidence rate is around 30% to 50%, of which clinical symptoms appear about 10% [2,3]. Not only seriously affect people’s quality of life, can also cause poor control of blood sugar fluctuations and to promote the occurrence of diabetes and development of chronic complications [4], therefore, DGP is a research hotspot in recent years. Now this year, Chinese and Western Medicine diabetic gastroparesis research are summarized below. 1 Pathogenesis 1.1 The autonomic nervous system and the enteric nervous system (ENS) lesions lead to delayed gastric emptying, autonomic nervous system, including sympathetic and parasympathetic nerves, the former main nerve endings of dopamine and norepinephrine release, with the role of inhibition of gastric peristalsis; the latter the main nerve endings the release of acetylcholine, can promote gastrointestinal peristalsis; study confirmed that the vagus nerve vagus nerve resection lesions and gastric motility can weaken or disappear, resulting in gastroparesis. Histological studies have shown that: Diabetic patients with vagus nerve, sympathetic, parasympathetic ganglia degeneration, with vacuole formation and demyelination, gastrointestinal submucosal plexus, myenteric plexus ganglion cells have varying degrees of chromatolysis, cell vacuolar degeneration and nuclear pulp necrosis [5]; nerve immunohistochemical study found that the gastric antrum of diabetic rats submucosal plexus, myenteric plexus significantly reduced, and the t