Double Dan oral cyclophosphamide in rat femur biomechanics and biochemical indexes.docVIP

 PAGE \* MERGEFORMAT 12 Double Dan oral cyclophosphamide in rat femur biomechanics and biochemical indexes 【Abstract】 Objective To observe the double-Dan oral cyclophosphamide in rats caused by osteoporosis models. Methods 4.5 mg * kg-1 * d-1 of cyclophosphamide gavage to rats, continuous 15 d, caused by osteoporosis model; double-Dan preventive oral administration, and with the positive drug carbonate Calcium D-dimensional comparison. After the end of the experiment, take the right rat femur bone biomechanical testing, followed by detection of bone calcium, phosphorus, magnesium, and hydroxyproline content. The results clearly lead to cyclophosphamide in rat femur bone loss of organic matter and minerals, bio-mechanical performance degradation, double-Dan oral liquid can effectively antagonize these effects, and the effect of dimension D and calcium carbonate rather. Conclusion Shuangdan Oral caused by cyclophosphamide can be effective in preventing bone loss in rat femur and bone quality. Keywords: double-Dan oral cyclophosphamide in rat bone mineral calcium carbonate, D-dimensional bone biomechanics Abstract: ObjectiveTo study osteoporosis of cyclophosphamide and investigate the preventive effects of Shuangdan oral liquid on rats.MethodsCyclophosphamide at the dose of 4.5 mg * kg-1 * d-1 was given to the rats orally for 15 days while Shuangdan oral liquid and calcium and vitamin D3 were given to cyclophosphamide-treated rats orally. At the experiment, bone biomechanics analysis of the right femur were performed in fresh sections. Then the hydroxyproline, Ca, P, Mg of bone were tested.ResultsBiomechanics property and bone mineral on femur of rats decreased significantly.ConclusionShuangdan oral liquid can prevent osteopathologic change from cyclophosphamide-induced on rats. Keywords:: Shuangdan oral liquid; Cyclophosphamide; Calcium and vitamin D3; Rats; Bone mineral; Bone biomechanics Oral pairs recorded in the 2005 e