Drug-eluting stents in the interventional treatment of coronary restenosis Research Status.docVIP

 PAGE \* MERGEFORMAT 12 Drug-eluting stents in the interventional treatment of coronary restenosis Research Status [Keywords:] Coronary Artery Disease [Keywords:] Coronary artery disease; drug-eluting stent; restenosis; Review literature 0 Introduction Coronary heart disease is a serious threat to human life, one of the diseases, to date there are two main technologies used in clinical coronary intervention, percutaneous transluminal coronary angioplasty (PTCA) and coronary stent implantation. Since 1977 has been applied restenosis problem has affected the long-term efficacy of PTCA, despite the subsequent coronary stent implantation significantly reduced restenosis rate, but there are 10% ~ 50% of the cases have occurred in-stent restenosis, the problem of restenosis, a coronary intervention treatment of one of the main problems. for the prevention and treatment of restenosis, has made many efforts, such as: pilot study of a large number of oral medication had not received satisfactory results, radiotherapy was considered a more effective method, but also because of the efficacy and safety issues without a wider application of [1]. In recent years, with a gradual understanding of the mechanism of restenosis, attached to a variety of drug-eluting stent has emerged to coronary intervention has brought the dawn, this article on the drug-eluting stents in coronary the treatment of restenosis are reviewed. A drug-eluting stent 1.1 The coating methods used in clinical multi-bracket made of metal, drug-eluting stent is a drug carrier, either directly or through appropriate traditional metal coating on the stent surface, becoming part of drug delivery systems. Vector is caused by a one or more kinds of organic compounds to form polymers, common are: acrylic acid methyl ester, chondroitin sulfate, poly lactic acid, phosphoric acid, choline, etc., have good biocompatibility, can reduce the local inflammatory response, reduce the incidence of thrombosis. while the