研究生讲座-肿瘤微环境简介.pptVIP

肿瘤微环境简介;;;Sid P. Kerkar and Nicholas P. Restifo. Cancer Res 2012;72:3125-3130.;肿瘤研究≠肿瘤细胞研究;肿瘤的免疫编辑;Dunn G,et al.Nature immunology. 2002.3(11):991;Solid tumors reach a certain size: Grow invasively, require an enhanced blood supply. Inflammatory signals leading to recruitment of cells of innate immune system: macrophages, DCs, γδ-T, NK and NKT. Produce IFN-γ;The initial IFN-γ starts a cascade of immune response: 1.Induction of chemokines:CXCL10,CXCL9,CXCL11.Block neovascularization of tumor, recruit macrophages, DCs ,γδ-T, NK and other immune cells. 2.Antiproliferation of developing tumor. 3.T