Effect of candesartan on arterial elasticity in patients with hypertension Comparison of the effects observed.doc

 PAGE \* MERGEFORMAT 11 Effect of candesartan on arterial elasticity in patients with hypertension Comparison of the effects observed [Abstract] Objective: To evaluate the candesartan on arterial elasticity in the step-down at the same time to improve results. Methods: 48 patients with hypertension were randomly divided into treatment group and the candesartan hydrochlorothiazide group, 24 patients in each group were given candesartan (8mg · d-1) and hydrochlorothiazide (25mg · d-1) line antihypertensive therapy, if blood pressure is not satisfactory in both groups plus felodipine (5mg · d-1), in the treatment of After 20 weeks before treatment and blood pressure were measured carotid - femoral pulse wave velocity (C FPWV). Results: In both groups no significant difference in the level of blood pressure cases (Pgt; 0.05), candesartan group C FPWV values #8203;#8203;after treatment compared with hydrochlorothiazide group was significantly decreased (P lt;0.05). Conclusion: Candesartan significantly improved arterial elasticity, this improving function and blood pressure itself and related factors other than blood pressure. [Keywords:] candesartan; Hypertension; artery elasticity; C FPWV High blood pressure is a global disease, stroke and other complications caused by the heart has become the number one killer of threat to human health. Has been a growing number of studies have shown that large artery elasticity decreased hypertension buffer dysfunction is to generate these important foundation of complications, reduce the danger of arterial elasticity is a growing concern. artery elasticity in the detection method, the determination of aortic pulse wave velocity (PWV) as a simple method with high predictive value and are increasingly be respected. Laurent, etc. of 1715 cases of patients with essential hypertension measure PWV, mean follow up 7.9 years. Cox regression model analysis showed that, PWV for each additional 4 m / s, the relative risk of fatal