Effect of pravastatin on acute coronary syndrome Vascular Endothelial Function.docVIP

 PAGE \* MERGEFORMAT 5 Effect of pravastatin on acute coronary syndrome Vascular Endothelial Function [Abstract] Objective To study the acute coronary syndrome patients with pravastatin therapy on vascular endothelial function effects. Methods 68 patients with acute coronary syndrome were randomly divided into pravastatin treatment group (34 cases) and routine treatment group (34 cases), compared before and after treatment of brachial artery ultrasound control of diastolic function and reductase Determination of nitric oxide in blood concentration. Results pravastatin treatment endothelium-dependent vasodilation improved significantly, nitric oxide concentrations increased significantly (P amp;lt;0.05). Conclusions Patients with acute coronary syndrome lipid-lowering therapy with pravastatin improves endothelium-dependent relaxing function. [Keywords:] pravastatin; acute coronary syndrome; vascular endothelium; diastolic function Acute coronary syndrome (acute coronary syndromes, ACS), including acute myocardial infarction (acute myocardial infarction, AMI) and unstable angina (unstable angina pectoris, UAP), is a common disease, the prognosis is poor, research showed that endothelial dysfunction is not only triggered by an early atherosclerosis, but also in the development of plaques play an important role, at present agreed that the statin-based cholesterol-lowering treatment is the prevention and treatment of atherosclerosis, coronary heart disease example. However, independent of lipid effects, the statins have many other pharmacological effects [1], such as anti-oxidation, to improve endothelial function such as [2]. In this paper, observation of ACS patients with pravastatin on vascular endothelial function effects to explore its possible mechanism of prevention and treatment of coronary heart disease. An object and methods 1.1 The object of study 68 patients with select ACS were randomly divided into pravastatin group 34 patients, 20 males a