Effect of simvastatin on rat pulmonary hypertension induced by high pulmonary blood flow in the intervention study.docVIP

 PAGE \* MERGEFORMAT 13 Effect of simvastatin on rat pulmonary hypertension induced by high pulmonary blood flow in the intervention study [Abstract] Objective: To observe the high pulmonary blood flow lead to pulmonary hypertension pulmonary vascular pathological changes, and understand the simvastatin (Simvastatin on pulmonary hypertension in rats. METHODS: Rat abdominal aorta - the inferior vena cava shunt, the establishment of pulmonary hypertension induced by high pulmonary blood flow in an animal model, given simvastatin 2 mg kg-1 d-1 after 11 weeks of intervention in pulmonary artery pressure measurement, testing the percentage of small pulmonary arteries, lungs, small muscular artery walls muscle thickness of the total external diameter (WT%, muscular blood vessel wall area percentage of total vascular area (WA%, and pulmonary vascular obstruction score (vascular occlusion score, VOS, and with the normal group and the control group. Results: Xin Simvastatin can reduce pulmonary artery pressure better, reducing the percentage of pulmonary muscular arteries, reducing WT% and WA% and can better prevent the pulmonary artery obstruction. Conclusion: Simvastatin on the high pulmonary blood flow caused by pulmonary hypertension better intervention effect. [Keywords:] pulmonary hypertension, simvastatin, high pulmonary blood flow [Abstract] Objective: To observe the change of pathology in pulmonary vascular when pulmonary hypertension induced by high pulmonary blood flow happens and comprehend the intervention effects of Simvastatin in pulmonary hypertension.Methods: Abdominal aorta inferior vena cava shunting was made in rats to establish animal model of pulmonary hypertension induced by high pulmonary blood flow, Simvastatin with dose of 2 mg kg-1 d-1 interfered for 11 weeks.And then, pulmonary arterial pressure, tri type pulmonary arteriole percentage, ratio of vascular wall area / total vascular area (WA% and ratio of vascular wall thickness /