ELISA assay of serum gastrin-releasing peptide precursor system diagnostic evaluation of small cell lung cancer.docVIP

 PAGE \* MERGEFORMAT 19 ELISA assay of serum gastrin-releasing peptide precursor system diagnostic evaluation of small cell lung cancer Study: Pro Yang Wei, Zhang Wei, Zhang Lin, Liu Xiaoli, Yang Shuan-profit [Abstract] Objective To evaluate the enzyme-linked immunosorbent assay (ELISA), the precursor of serum gastrin-releasing peptide (Pro-GRP) diagnosis of small cell lung cancer (SCLC) in value. Methods We searched PubMed, Cochrane, ISI Web of Knowledge and other databases Retrieval time from 1990 to literature published in 2009, collecting information on ELISA, serum Pro-GRP diagnosis of SCLC in the literature and statistics of information, scientific evaluation and quality grading; using Meta-Disc1.4 software for data analysis; by pooled sensitivity, specificity, likelihood ratio and summary receiver operating characteristic curve Summary (SROC curve) comprehensive assessment of statistical indicators such as ELISA, serum Pro-GRP in early diagnosis of SCLC. Results Total 11 documents, which 6 English literature, Chinese literature 5, sample size was 3,554 cases, which confirmed by pathology for the 1122 cases of SCLC, NSCLC for the 2432 cases. heterogeneity test showed a good homogeneity of the included studies, summarized by determining the model calculated the pooled sensitivity was 0.75 (0.73,0.78), summarizes the specificity was 0.93 (0.92,0.94), summary positive likelihood ratio 11.44, negative likelihood ratio of aggregate 0.27, SROC area under the curve was 0.93. Conclusions Pro-GRP in the early diagnosis of SCLC has some reference value can be used as reference for one of the more important. [Keywords:] gastrin-releasing peptide precursor; tumor markers; small cell lung cancer; ELISA method; Meta Analysis ABSTRACT: ObjectiveTo evaluate the diagnostic value of serum pro-gastrin-releasing peptide (Pro-GRP) in patients with small cell lung cancer (SCLC) through ELISA method.MethodsWe searched PubMed, Cochrane, ISI Web of Knowledge and other