Electrical nerve stimulation for epilepsy therapy progress.docVIP

 PAGE \* MERGEFORMAT 19 Electrical nerve stimulation for epilepsy therapy progress [Keywords:] epilepsy, nerve electrical stimulation, treatment With classic antiepileptic drugs (Antiepileptic drugs, AEDs, and the rational application of the continual emergence of new drugs, the majority of seizures can be controlled better, but still about 30% of epilepsy patients are not sensitive to a variety of AEDs [1] and about 50% of epileptic patients receiving drug treatment, apparent side effects, and affect their quality of life. in drug refractory epilepsy patients, only about 50% of the patients with resection of epileptic foci for surgical indications. Thus, since 1954, first described by Penfield amp; Jasper cortical electrical stimulation can reduce seizures, the countries of scholars actively seek to change cortical excitability in epilepsy treatment methods, such as subdural cerebellar stimulation, electrical stimulation of cortical epileptogenic focus surgery (Electric cortical stimulation, ECS), deep brain stimulation (Deep brain stimulation, DBS, and repetitive transcranial magnetic stimulation (Repetitive transcranial magnetic stimulation, rTMS and other central nervous system stimulation, and vagus nerve stimulation (Vagal nerve stimulation, VNS, trigeminal nerve stimulation (Trigeminal nerve stimulation, TNS loaded with peripheral nerve stimulation, in order to control the seizures. With electrophysiological, microelectronics and computer technology is developing rapidly, the magnetic stimulation for seizure control has been achieved so encouraging progress. This article focuses on the ECS, DBS of the basic research and clinical application to make an introduction. 1, electrical stimulation of the cortex 1.1 Electrical stimulation of the cortex neurophysiological mechanisms of seizures in some previous studies have shown that patients with epilepsy cortical excitatory and inhibitory function in an unbalanced state [2]. Weiss, etc. will 1Hz ,5