Elderly patients with gastric tumors in vitro sensitivity to chemotherapeutic drugs and the relationship between the expression of COX2.docVIP

 PAGE \* MERGEFORMAT 13 Elderly patients with gastric tumors in vitro sensitivity to chemotherapeutic drugs and the relationship between the expression of COX2 Of: blue Wusheng Chun Han Jie Liu Xuejun Tan [Abstract] in elderly patients with gastric cancer cells in vitro sensitivity to chemotherapeutic drugs and tumor cyclooxygenase 2 (COX 2 expression and its significance. Methods 50 elderly patients (gt; = 60 years) and 35 cases of gastric cancer patients in control group MTT method in patients with tumor cells in primary culture drug sensitivity test and immunohistochemical staining for COX 2 expression, simultaneous detection of multiple drug resistance factors in tumor tissue P glycoprotein (P gp, glutathione S transferase (GST , DNA topoisomerase @ (Topo @ protein. Results 5 FU, L OHP, eADM, MMC, VCR on the inhibition of tumor cells in elderly patients was lower than the control group (all P lt;0.05. geriatric group COX 2 expressed higher (P lt;0.05, older group of multidrug resistance-associated factor P gp, GST expression was significantly higher (both P lt;0.05, control group was significantly higher than that of Topo @ old group (P lt;0.01, COX 2 expression in elderly patients with P gp, GST were positively correlated (all P lt;0.05, with the Topo @ expression was negatively correlated (P lt;0.05, in the control group, only found in the expression of COX 2 and P gp a positive correlation (P lt;0.05. elderly patients with COX 2 expression in gastric cancer with 5 FU, PTX, L OHP, eADM inhibitory rate of tumor cells was negatively correlated (all P lt;0.05), while the control group, while the expression of COX 2 and 5 FU, HCPT, VCR inhibition rate of tumor cells have a negative correlation (all P lt;0.05. Conclusions Elderly patients with gastric cancer cells more than in the control group, multidrug resistance, which may be more elderly patients with COX 2 expression strongly related. [Keywords:] gastric cancer, elderly, chemotherapy drug