Elderly patients with functional bowel disorders chymase gene polymorphisms.docVIP

 PAGE \* MERGEFORMAT 16 Elderly patients with functional bowel disorders chymase gene polymorphisms OF: HEALTH CARE spring quarter of Sun Hung Like Xu Xiaobing Liu Yu Hong Zhang Zhao is new in Zheng Lei Gong Weizhong Zhang Zhiliang Abstract Objective functional bowel disorder in elderly (FBD) in patients with chymase (CMA) B species gene A / G polymorphism of the characteristics of the combined blood pressure, cardiac structural abnormalities, kidney dysfunction and other target organs The clinical significance of harm. Methods 89 cases of elderly patients with FBD, according to their disease in functional gastrointestinal Rome criteria carved type, all patients with sequential number into 4 subgroups, including irritable bowel syndrome (C1; n = 17), functional bloating (C2; n = 22), functional constipation (C3; n = 27), functional diarrhea (C4; n = 23), and select the non-FBD elderly patients as a control group (C; n = 22), using sequence-specific primers polymerase chain reaction detection of circulating blood of patients in each group B species of CMA gene A / G polymorphism in the frequency of the selected patients were divided into FBD homozygous GG genotype group (n = 51), and other bits with A homozygous genotype AA and heterozygous AG group (n = 38), and conduct comparative analysis of two sets of clinical indicators. Results of total group CMA gene FBD GG genotype, G allele frequency was 57.30%, 76.40%, 54.55% in control group, 75%, but not statistically significant (gt; 0.05), FBD GG genotype BMI, Cr, SBP, DBP, UAE, LVD, IVSD, LVPWD, LVMI was significantly higher than that of the clinical indicators of AA and AG genotype ( lt;0.05). FBD four groups of 1 to 3 the total prevalence of hypertension was 84.26% (75/89), with the control group (59.09%; 13/22) differ significantly (P lt;0.01), C1 group, C2 group, C3 group C4 group of 1 to 3 with hypertension were 70.59% (12/17), 95.45% (21/22), 92.59% (25/27), 73.91% (17/23), higher than 59.09% (