Endotoxemia cytokines in hemorrhagic shock role in the development process and the therapeutic strategy.docVIP

 PAGE \* MERGEFORMAT 13 Endotoxemia cytokines in hemorrhagic shock role in the development process and the therapeutic strategy Keywords:: hemorrhagic shock endotoxin cytokine therapy Hemorrhagic shock is clinically one of the more common of the critically ill patients, the main treatment is to supplement the blood volume, the application step-up drugs. However, some patients even if the blood volume has been filled, step-up to a maximum dose of medicinal, shock can not be corrected, eventually death. Therefore, the treatment of refractory shock to become a major clinical difficulties, a thorough understanding of the pathogenesis of shock is the key to targeted therapies. In recent years, for bacterial and endotoxin translocation, cytokines such as in hemorrhagic shock by the irreversible process of development can reverse the role of in-depth research, has made great progress in the treatment of clinical shock and provides some theoretical basis for the this paper, which are reviewed. A gut-derived bacteremia, the role of endotoxemia 1.1 bacteremia during hemorrhagic shock, endotoxemia many studies have found that after the occurrence of hemorrhagic shock, there is a clear endotoxin, endotoxin shock and resuscitation continued existence of [1 ~ 3]. But for bacteremia, endotoxemia are meaningless in the shock and the development of controversy have emerged. Some people think that after hemorrhagic shock complicated by endotoxemia in the course of only a shock of a physiological phenomenon, may be without any pathological significance. However, most scholars believe that bacteremia after hemorrhagic shock, endotoxemia is to promote the irreversibility of shock to one of the important reasons for conversion, with a clear relationship between the prognosis of shock [4,5]. Endotoxemia which has more than bacteremia important, because endotoxemia can induce a large number of inflammatory factors released into the blood, an excessive amount of inflammatory factor