Endothelial progenitor cells in ischemic heart disease in the research.docVIP

 PAGE \* MERGEFORMAT 13 Endothelial progenitor cells in ischemic heart disease in the research Abstract Ischemic heart disease is a kind of serious threat to human health disorders, its occurrence, development and prognosis of vascular endothelial closely related. Study found that endothelial progenitor cells are also involved in endothelial repair and after birth, the process of angiogenesis, suggesting that in ischemic heart disease important treatment role and prospects for clinical application. Keywords: endothelial progenitor cells in ischemic heart disease overview Endothelial progenitor cells (EPC) is a vascular endothelial precursor cells, also known as vascular cells (angioblast), is a class of wandering, proliferation and can differentiate into vascular endothelial cells, but the lack of mature endothelial cell phenotype, nor the formation of blood vessels precursor cells [1]. Ischemic heart disease, particularly myocardial infarction, one of the diseases is very high fatality rate, as people’s living standards improve, the incidence rate was significantly increased, their treatment includes drug therapy, interventional therapy and surgery, but the endothelial progenitor cells in the promotion of vascular and myocardial regeneration prospects for the development of its treatment has undergone profound changes. 1 EPC source In 1997, Asahara, who first isolated and confirmed the presence of an adult peripheral blood can be differentiated into vascular endothelial cells, endothelial progenitor cells (endothelial progenitor cells, EPC), and in vivo proof of its ability to generate blood vessels [2]. It is not only involved in angiogenesis in the embryonic period, but also after birth are also involved in angiogenesis process [3]. In the embryonic development, the yolk sac extraembryonic mesoderm of some mesenchymal cells gradually gathered into a cord or lumps to form blood islands. These cells appear compartment of g