Ephedra fruit polysaccharides in rabbit ventricular papillary myoelectric activity of.docVIP

 PAGE \* MERGEFORMAT 15 Ephedra fruit polysaccharides in rabbit ventricular papillary myoelectric activity of 【Abstract】 Objective To observe the Ephedra fruit polysaccharide on isolated rabbit ventricular papillary muscle action potentials, and to explore its mechanism. Methods glass microelectrode method of intracellular records, trace recorded ephedra fruit polysaccharides on ventricular papillary muscle resting potential (RP), action potential amplitude (APA), 0 maximal depolarization velocity (Vmax), re-extreme 50 % and 90% (APD50, APD90) of the time of impact and the use of M receptor blocker and β-receptor blocker, to explore the role of the target. The results of ephedra, when too much sugar, 5 min reperfusion, APD, APD50, APD90 was significantly prolonged gradually after shortening; 10 min, the three indicators and significantly shorter than the control group. After the application of M receptor blocker, the effect is gone; application of β-receptor blocker, the first post-shortening effect of the extension still exist. Conclusion Ephedra fruit polysaccharides acting on the ventricular papillary muscle M receptor inhibition of K channels are the first post-facilitated two-way effect. Keywords: Ephedra fruit polysaccharides ventricular papillary muscle action potential Effect of Ephedra vulgans Fruit Polysaccharide (EVFP) on Electric Potential of Ventricular Papillary Muscle in Rabbits AbstractObjectiveTo observe the effects and the mechanism of EVFP on electric potential of ventricular papillary muscle in rabbits. MethodsThe electric potentials of isolated ventricular papillary muscle were intracellularly recorded. Electrophysiological parameters were: resting potential (RP), amplitude of action potential (APA), maximal rate of depolarization of phase 0 (Vmax), duration of action potential (APD), duration of 50% and 90% depolarization (APD50 and APD90). The effects and mechanisms of action EVFP on the electric potentials wer