Ephedrine chiral isomers and acid congeners alone and compatibility of histamine antagonists to stimulate contraction of isolated guinea pig tracheal pharmacological studies on film.docVIP

 PAGE \* MERGEFORMAT 9 Ephedrine chiral isomers and acid congeners alone and compatibility of histamine antagonists to stimulate contraction of isolated guinea pig tracheal pharmacological studies on film Author: Hong-Yu Li, Lu Xin-huai, Ding Gao, Zhang Tian-hong, ZHAO Jian, DU Xian-Lin [Abstract] Objective film based on the principle of bile Ma, evaluation of various ephedrine isomers and the acid homologue antagonize histamine stimulated contraction of isolated guinea pig trachea film roles, from various faculties were selected potent compounds monomer and to compare the two drugs alone and the role of strong and weak compatibility in order to achieve the purpose of enhancing efficacy to reduce side effects for anti-asthma drug development to provide experimental basis. Methods histamine stimulated contraction of isolated guinea pig trachea-chip model, with colorful sets Med-lab-u/4cs biological signal processing system, after recording dosing changes in tracheal tension to compare the different chiral isomers of ephedrine and the acid homologue alone and combinations on histamine antagonism. The results of D-ephedrine and deoxycholic acid on histamine antagonism stronger. According to both the ED50, D-ephedrine and deoxycholic acid by 4:1 compatibility with both single-use comparison, the pharmacological effects enhanced, dose-effect curve to the left. Conclusion The synergistic effect between the combination, suggesting that the two combined treatment of bronchial asthma can reduce the dose of ephedrine, thus reducing side effects. [Keywords:] D-ephedrine; deoxycholic acid; in vitro experiment [Abstract] Objective To find evidences for a new combination of 1S, 2R-() Ephedrine hydrochloride and Deoxycholic acid in the treatment of asthma.Methods Med-lab-u/4cs system was used to record the changes of the strain of guinea pig tracheal after drug administration, and the antagonistic effects of the two isomers of both ephedrine and psudoephedrine, and deoxyc