Epimedium flavone on observation of the influence of sleepawakening.docVIP

 PAGE \* MERGEFORMAT 8 Epimedium flavone on observation of the influence of sleepawakening Of: Fu Libo Xuebin Liu Fenglian [Abstract] Objective To observe the intracerebroventricular injection of TFE (total flavonoids of Epimedium, TFE on sleep and wake activity in rats. Methods stereotaxic technique using the ICV microinjection of TFE, recorded by polysomnography technique described (PSG) on rat sleep-wake TFE observed activities. The results in rats induced by intracerebroventricular injection of TFE slow wave sleep time (SWS) and total sleep time (TST) increased arousal (W) time is reduced, intracerebroventricular injection of bicuculline alkali (Bic increase W, reduce the fast wave sleep (PS, ICV injection of TFE and Bic were both of sleep and W had no significant effect. Conclusion TFE can promote sleep, inhibition of awakening, that TFE has a clear central inhibition. [Keywords:] intracerebroventricular injection, Epimedium total flavonoids, sleep, wake Li has been in the “lt;Compendium of Materia Medicagt;gt; mentioned in Epimedium (Herba Epimedium, HE has” Yijing gas, Kennedy bones, make up waist, strong effort, “the effect of (1). HE is the main active ingredient is Longspur hopane total flavonoids (TFE and Epimedium polysaccharide (EPS, clinical and pharmacological effects of recent years many reports (2 ~ 4). Yanjin Ling et al (5) HE has studied the water extract of sleep function and spontaneous activity in mice effects of water extract proved HE inhibit the central nervous system, could inhibit the spontaneous activity, but can also significantly prolong the sleeping time, with a hypnotic effect, Zhu Guoqing, etc. (6) of ICV injection of cAMP and ATP on the big rats of sleep. But TFE effects on sleep-wake activity was no in-depth coverage. the present study, intracerebroventricular injection of TFE, TFE analysis on rat sleep-wake activity cycle. 1 Materials and methods 1.1 The use of experimental animals, 200 ~ 260 g adult Wistar