Epinephrine on guinea pig left ventricular outflow tract of spontaneous activities.docVIP

 PAGE \* MERGEFORMAT 9 Epinephrine on guinea pig left ventricular outflow tract of spontaneous activities Of: Chen Lifeng Xu Taofan Yinwan Bin Zhao Lanping Sun Lin Ling Chen Shaofeng [Abstract] Objective: To observe the epinephrine (E) on guinea pig left ventricular outflow tract spontaneous slow action potentials. Methods: The standard glass microelectrode intracellular recording technique to observe the E on guinea pig left ventricular outflow Road organizations Spontaneous Slow Potential. observations are: maximal diastolic potential (MDP), action potential amplitude (APA), 0 on the maximum rate of depolarization (Vmax), 4 speed of automatic depolarization (VDD), the spontaneous discharge rate (RPF), 50% repolarization and 90% of the time (APD50, APD90). Results: 100mol/LE perfused guinea pig left ventricular outflow tract APA self-regulatory organization action potential significantly increased (P lt;0.01), Vmax significantly increased (P lt;0.05), MDP significantly increased (P lt;0.05), APD90 was significantly reduced (P lt;0.01); RPF significantly increased (P lt;0.01), VDD markedly accelerated (P lt;0.05). Conclusion: E on left ventricular outflow tract pacemaker cells a stimulant. [Keywords:] adrenaline; Electrophysiological techniques / heart; guinea pig; left ventricular outflow through; pacemaker cells As is a clinical cardiac stimulant, the epinephrine (E) has very important function in the cardiovascular system, but the effects on ventricular outflow tract cells haven t been deeply reseached. The ventricular outflow tract used to be thought a hemal outflow path.With the development of clinical electrophysiology examination and radio frequency ablation technique in recent years, it was discovered that some arhythmias had relation with the abnormality of structure, appearance and function of ventricular outflow tract. By using standard intracellular microelectrode technique to record Aps, epinephrine was used to investigate the electrop