Epithelial cadherin E and β catenin expression in pancreatic cancer.docVIP

 PAGE \* MERGEFORMAT 8 Epithelial cadherin E and β catenin expression in pancreatic cancer [Abstract] Objective: To study the epithelial cadherin E (E cad) and β-catenin (β cat) expression in pancreatic cancer and its clinical significance: the use of immunohistochemistry to detect epithelial cadherin E and β-catenin in pancreatic cancer and adjacent non-tumor tissues of the pancreas. and analyze its relationship with clinicopathological factors results: epithelial cadherin E and β-catenin protein in pancreatic cancer tissues was significantly lower than the adjacent non-neoplastic pancreatic tissue. Conclusion: epithelial cadherin E and β-catenin protein expression may be involved in the low transfer of pancreatic cancer, combined detection of pancreatic cancer diagnosis and prognosis to determine a certain value. [Keywords] Pancreatic immunohistochemical epithelial cadherin E β-catenin Abstract Objective: This experiment is to explore the expression and clinical significance of β catenin and E cadherin in pancreatic cancer tissue and cells.Methods: The expression of β catenin and E cadherin in pancreatic carcinomas and adjacent noncancer tissues were studied by immunohistochemistry, and their relationship to clinicopathological characteristics were analyzed.Results: In pancreatic carcinomas tissues showed reduced β catenin and E cad expression which compared with adjacent non cancer tissues.Conclusion: The expression of β catenin and E cadherin may together be involved in the development and progression of pancreatic cancer.The combined measurement of these two proteins may be useful for determination of metastatic potency of pancreatic carcinoma. Keywords: pancreatic carcinoma, immunohistochemistry, E cadherin, β catenin Pancreatic cancer is a common pancreatic tumor, mostly late diagnosis, radical surgery, lost time, 1-year survival after diagnosis in patients less than 10%, 5-year survival rate of lt;1%, the worst prognosis of malignant tumo