EPO on hemorrhagic shock with endotoxemia rabbit TNF IL6 IL10 MDA impact of.docVIP

 PAGE \* MERGEFORMAT 14 EPO on hemorrhagic shock with endotoxemia rabbit TNF IL6 IL10 MDA impact of [Abstract] [Objective] To investigate endotoxemia induced lipid peroxidation in rabbits, changes in inflammatory factors, the use of erythropoietin (EPO) to intervene. [Method] rabbit femoral artery bleeding shock and subsequent recovery in manufacturing, to the intraperitoneal injection endotoxin in rabbit caused by two hit model of multiple organ dysfunction syndrome; 24 healthy New Zealand rabbits were randomly divided into control group, two-hit group, EPO group, n = 8; sacrificing blood samples before and after modeling for the detection of TNF @, IL6, IL10, MDA and other indicators. [results] two hits caused by MDA levels were significantly higher than the other two groups, EPO group MDA levels were significantly lower than the second attack; second hit caused by the other two TNF @, IL6, IL10 levels were significantly higher than the control, EPO was significantly lower than the two-hit group. [Conclusion] TNF @, IL 6, IL 10 and other inflammatory factors such as lipid peroxidation products MDA involved in hemorrhagic shock with endotoxin hyperlipidemia due to multiple organ damage in the process, EPO can reduce hemorrhagic shock with endotoxemia in rabbits with inflammatory factors and lipid peroxidation levels. [Keywords:] Endotoxemia; erythropoietin; multiple organ dysfunction syndrome; inflammatory factor Abstract: [Objective] To explore the rabbits’ lipid peroxidation and cytokine level change caused by endotoxemia, use EPO for intervention. [Method] Bleed rabbits femoral for shock, after coming to, make injection of endotoxin, two beatings make dysfunctional multi organs model ; randomly divide 24 healthy rabbits into control group (1), 2 beating group (2), EPO group (3), 8 in each; take blood for testing indexes of TNF @, IL6, IL10 and MDA. [Result] Group 2 was higher than other groups on MDA level, group 3 less than group 2; group 2 was mu