Eplerenone tablets HPLC determination of.docVIP

 PAGE \* MERGEFORMAT 7 Eplerenone tablets HPLC determination of [Abstract] were measured using HPLC Eplerenone tablets. Methods Kromasil C18 (250mm * 4.6mm, 5μ m), acetonitrile - water (30:70) as mobile phase, detection wavelength 244nm, flow rate 1ml/min. The results of Eplerenone in the range of 20.144 ~ 201.440μ g/ml a good linear relationship, method, average recovery was 98.7% (RSD = 0.63%). Conclusion The method is simple and reliable and can be used for eplerenone tablets quality control. [Keywords:] Eplerenone Tablets by High Performance Liquid Chromatography [Abstract] Objective To establish the HPLC method for the determination of related substances in Eplerenone tablets.Methods Kromasil C18 (250mm * 4.6mm, 5μ m) was used with a mixture of acetonitrile-water (30:70), as the mobile Bhase. The flow rate was 1.0ml/min and the detective wavelength was 244nm.Results It had a good linearity over the concertration range of 20.144 ~ 201.440μ g/ml. The average recovery was98.7% with RSD of 0.63%. Conclusion The method for the determination of Eplerenone Tablets by HPLC is simple and accurate. It can be used for the quality control of Eplerenone Tablets. [Keywords:] Eplerenone tablet; HPLC; determination Eplerenone [1] (Eplerenone) the grounds Pfizer / Pharmacia Corporation jointly developed the first listing of an approved new selective aldosterone receptor blocker, with pairs of aldosterone receptor selectivity, step-down effect is good , effect and lasting advantages, and or reverse, reduce the number of aldosterone receptors on the cardiovascular adverse effects, which control high blood pressure, prevention and target organ damage related to cardiovascular disease, to improve the anti-hypertensive patients are important. In order to effectively control the product quality, and this paper, HPLC method [2] Determination of the content of eplerenone results showed that the method is simple and accurate. An instrument and reagent Shimadzu LC-10AT hi