Epimedium extract of the estrogen-like effects.docVIP

 PAGE \* MERGEFORMAT 15 Epimedium extract of the estrogen-like effects Of: Yu Yan, Yan Hong, Hu Sunoco, Zhang Jinghua [Abstract] Objective To evaluate the Epimedium extract of estrogen-like effects. Methods mouse uterine weight test, estrogen receptor-positive cell lines (MCF 7) cell proliferation and antagonistic test, evaluation and Epimedium Epimedium glycoside estrogenic effects and its possible mechanism. The results with the negative control group, icariin Epimedium and uterine factors can significantly increase from the 0.097 + -0.008 -0.018 to 0.156 and 0.152 + -0.016 +, and medication before and after the weight of the animals (18.9 + -1.3) g, respectively, increased to (19.8 + -1.3) g and (20.03 + -1.3) g, significantly higher than the negative control group increased (P lt;0.05), icariin can E2 from the estrogen in serum (132.22 + -11.45) ng / L increased to (147.73 + -12.43) ng / L, FSH level from (50.15 + -3.36) g / L decreased to (44.47 + -2.46) g / L (P lt;0.05), but E2 levels of estrogen Epimedium group no significant change in 24,48,72 h, and Epimedium icariin on proliferation of MCF 7 cells were significantly promoted (P lt;0.05 ), respectively, by 0.238 + + -0.051,0.563 -0.043,0.387 -0.083 to 0.362 + + + -0.046,0.648 -0.045,0.521, and 0.324 + + -0.043 + -0.079 -0.034,0.622 -0.043,0.465 +, 72h after joining ICI, significantly inhibited cell proliferation, cell proliferation rates were reduced to 99.461%, 94.434%. Conclusions and icariin Epimedium has estrogen-like effect, and its role in promoting cell proliferation may be affected by estrogen body (ER) mediated production. [Keywords:] Epimedium estrogen-like effects ABSTRACT: Objective To investigate the estrogen like effects of Epimedium extractive. Methods By using the uterus growth test in mice and test of MCF 7 proliferation and adding estrogen receptor antagonist Icariin, we evaluated the estrogenic effects of Epimedium and Icariin and the possible mechanism. Results Epimediu