Esophageal basaloid squamous cell carcinoma - light microscopy electron microscopy and immunohistochemical study of.docVIP

 PAGE \* MERGEFORMAT 16 Esophageal basaloid squamous cell carcinoma - light microscopy electron microscopy and immunohistochemical study of Authors: Liwen Yan, Niu Feng-xia, Li-yun 【Abstract】 Objective To observe the esophageal basaloid squamous cell carcinoma (basaloid  squamous carcinoma, BSC) of the histological features, to explore the diagnosis and differential diagnosis. Methods 15 cases of BSC specimens for light microscopy, electron microscopy and immunohistochemical studies. Results BSC histology have many salivary adenoid cystic carcinoma (adenoid cystic carcinoma, ACC) similar characteristics. However, cancer cells divide less BSC strong atypia, cancer cells were the fence around the nest-like arrangement of tumor surface, often accompanied by squamous cell carcinoma in situ or superficial invasive squamous cell carcinoma; occasionally nest and surface squamous cancer connected to the basal low-level, or occasionally the formation of squamous cell carcinoma nests or duct-like structure, different from those with ACC. Ultrastructure and ACC similar, but less differentiated cancer cells and intracytoplasmic tonofilaments can be seen with the ACC different. Immunohistochemical Results: Basal cell-like components: CK (pan) 15/15, EMA 15/15, CEA 6 / 15, S  100 6 / 15, SMA 7 / 15 positive, the tumor contains epithelial and myoepithelial cells. Conclusion BSC is a relatively low differentiation, invasive stronger, there is the adenoid, squamous, and myoepithelial cell differentiation tendencies, unique clinical and pathological features of malignant tumors, their histological features can be used as diagnostic criteria of pathology, ultrastructure and immunohistochemical features supplement the differential diagnosis. Keywords: Esophageal cancer; Basaloid squamous cell carcinoma; Immunohistochemistry Basaloid Squamous Carcinoma of the Esophagus  Immunohistochemical, Light and Electron Microscopic Keywords:: Esophageal Neop