Fermented astragalus on BALB - C mice with immune function and the role of cytokines.docVIP

 PAGE \* MERGEFORMAT 11 Fermented astragalus on BALB / C mice with immune function and the role of cytokines Of: Wang Xiaobo, Liu Dianwu 2, Guo Lili, Wang Hua [Abstract] Objective To study the fermentation of Astragalus on immune function and cytokines. Methods The mice were randomly divided into control group, immunosuppression group and the control group and the fermented astragalus Astragalus low, medium and high three dose group (dose for the 1,2, 5 g / kg), fed mice Drinking Water Act, the following indicators were examined: thymus and spleen index, lymphocyte subsets, lymphocyte proliferation, macrophage phagocytosis, IL-1 , IL-2 secretion. The results were compared with immune suppression, fermented astragalus middle and high doses can significantly stimulate lymphocyte transformation, the CD3, CD4, CD4/CD8 were significantly increased, and promote peritoneal macrophage phagocytosis, and promote Interleukin -1 (IL-1) and interleukin -2 (IL-2) production (P all lt;0.05). fermented astragalus can improve the body’s immune function, its mechanism and activation of T cells, T lymphoid cell subsets, macrophage function and cytokine secretion. [Keywords:] fermented astragalus; immune function; cell factor; mice Astragalus commonly used as tonic herbs, has a solid form and the spleen qi Li Fei effect. At home and abroad Modern research has confirmed that Astragalus contains polysaccharides, glycosides, alkaloids, flavonoids, amino acids and other ingredients with trace elements The role of regulating immune function [1,2]. In order to further development of traditional Chinese medicine formulation of fermented astragalus and function in mice the role of the immune system, the secondary development of traditional Chinese medicine to provide the theoretical basis and application feasibility. 1 Materials and equipment 1.1 The health of animal and cell line BALB / C mice, male and female 7 to 8 weeks old, weighing 18 ~ 22 g, by the Experimental An