Fludarabine + Maryland pre-allogeneic hematopoietic stem cell transplantation in the treatment of leukemia observed.docVIP

 PAGE \* MERGEFORMAT 18 Fludarabine + Maryland pre-allogeneic hematopoietic stem cell transplantation in the treatment of leukemia observed Of: Wang Jianli, Zhang Wanggang, Caoxing Mei, Chen Yinxia, He Aili, Liu Jie, Ma Xiaorong, Yang Yun, ZHAO Wan-Hong, Yang Huiyun [Abstract] Objective To investigate the use of “busulfan + fludarabine (Flud + Bu)” line of conditioning regimen in allogeneic hematopoietic stem cell transplantation in the treatment of leukemia patients. Methods 6 patients with chronic myelogenous leukemia (CML) in chronic phase 2 cases of acute lymphoblastic leukemia (L2 type), 2 cases of acute non-lymphocytic leukemia (M5 type), 1 case of myelodysplastic syndrome (MDS) into acute leukemia in 1 case Feilin. conditioning regimen including fludarabine 30mg / (m2 d) 4d, injection Maryland 3.2mg / (kg d) 2 ~ 4d; non-blood transplant patients increases with rabbit anti-human thymocyte globulin (ATG) 2.5mg / (kg d) 3d; HLA matching donor for their fellow citizens or non-matched blood; infusion of peripheral blood stem cells in the total number of CD34 + cells 3.0 ~ 8.03 106/kg (average 4.29 106/kg), mononuclear cells were 6.74 ~ 13.51 108 / kg (average 9.01 108/kg); using “cyclosporine + short course methotrexate” Prevention of graft versus host disease (GVHD). the results of all patients no serious complications related to the pretreatment; which Hematopoietic reconstruction in 5 patients, peripheral blood leukocytes STR DNA are fully confirmed donor implantation; 1 case of acute lymphoblastic L2 after transplantation in patients with early (lt;30d) relapse leading to death, and the remaining 5 patients were followed up for 8 to 20 months (median 10 months) were alive without leukemia relapse so far. conclusion “of fludarabine + Maryland” light conditioning regimen transplant-related complications, treatment of hematologic malignancies is safe and feasible, long-term efficacy remains to be assessed. [Keywords:] hematopoietic stem