FolFox-6 chemotherapy in the treatment efficacy of colorectal cancer.docVIP

 PAGE \* MERGEFORMAT 17 FolFox-6 chemotherapy in the treatment efficacy of colorectal cancer Of: Wang Zhiyong, Tao Kaixiong, Lung Yeuk Ping, R. Bin Wong [Abstract] Objective To investigate neoadjuvant chemotherapy FolFox-6 in the treatment of colorectal cancer and its effect on postoperative complications and prognosis. Gastrointestinal Surgery in our hospital were screened in October 2005 ~ October 2008 appropriate colorectal cancer cases of 60 patients divided into two groups, treatment group (n = 28 by FolFox-6 program a preoperative chemotherapy, 14 days after the surgery; again by FolFox-6 after chemotherapy, 14 days repeat of chemotherapy 4 times. control group (n = 32 not to preoperative chemotherapy, postoperative chemotherapy with the same treatment group, the use of WHO recommended standards of solid tumors term effect of treatment group were evaluated after neoadjuvant chemotherapy to assess the efficacy of using the WHO anti-cancer drugs commonly occurring adverse reactions grading criteria to evaluate neoadjuvant chemotherapy side effects, statistics, postoperative complications, patient recovery, and two groups of patients were followed up to assess the prognosis. Results of neoadjuvant chemotherapy treatment group after the line rate ( more than 60% RR; neoadjuvant chemotherapy side effects were transient and mild; the incidence of postoperative complications were no significant differences; treatment group the local recurrence rate (13.04% lower than control group (31.03% ; two groups were long-term survival rates were 86.96% and 82.76%, the difference was not statistically significant. Conclusion Neoadjuvant chemotherapy for colorectal cancer can improve the efficacy of chemotherapy and reduce the local recurrence rate, but also the effect of long-term survival benefit for further observation. [Keywords:] colorectal cancer; neoadjuvant chemotherapy; prognosis; postoperative complications [Abstract] Objective To investigate and evalu