Gemcitabine combined with cisplatin treatment of advanced non-small cell lung cancer.docVIP

 PAGE \* MERGEFORMAT 11 Gemcitabine combined with cisplatin treatment of advanced non-small cell lung cancer Author: Guai Qin, Han Hui, Shen Jie, Qi Tai, Li Xiong Wen [Keywords:] non-small cell lung cancer; Gemcitabine; cis-platinum; chemotherapy [Abstract] Objective To observe the gemcitabine and cisplatin chemotherapy regimen (GP program) in the treatment of advanced non-small cell lung cancer (NSCLC) the clinical efficacy and toxicity. Methods 82 cases of stage Ⅲ and Ⅳ non-small cell lung cancer patients give GP regimen. Intravenous infusion of gemcitabine 1250mg/m2 the first 1,8 days, DDP 70 ~ 80mg/m2 intravenous infusion of 1 day, 21 days for a cycle, each patient treated for at least two cycles. Results All 30 patients with partial remission, stable in 44 cases, the progress in 8 cases; total effective rate was 36.6%. Effective the beginning of treatment were 43.2%, re-treatment were effective rate of 28.9%. The overall median survival was 9.2 months, one year survival rate was 37.8%. The most common toxicity was myelosuppression, Ⅲ ~ Ⅳ degree of white blood cell and platelet reduction rates were 28.0% and 24.4%, the remaining vestiges of minor side effects can be tolerated. Conclusion Gemcitabine combined with cisplatin chemotherapy in first-line therapy or second-line treatment of advanced non-small cell lung cancer have better efficacy and toxicity of light, well tolerated by patients. [Keywords:] non-small cell lung cancer; Gemcitabine; cis-platinum; chemotherapy Clinical observation of gemcitabine plus cisplatin in the treatment of advanced non-small cell lung cancer [Abstract] Objective To evaluate the therapeutic effects and toxicity reaction of gemcitabine plus cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods 82 patients with NSCLC in stage Ⅲ and Ⅳ were treated with gemcitabine 1250mg/m2 by intravenous infusion on 1st and 8th days, and cisplatin 70 ~ 80mg/m2 by intravenous infusion on 1st in a 21-day