Ginkgo biloba Chuanxiong agents and the treatment of bone marrow stromal cells in the experimental study of focal cerebral ischemia.docVIP

 PAGE \* MERGEFORMAT 14 Ginkgo biloba Chuanxiong agents and the treatment of bone marrow stromal cells in the experimental study of focal cerebral ischemia [Abstract] Objective To investigate the ginkgo, Chuanxiong preparation can make bone marrow stromal cells (MSCs) treatment of focal cerebral ischemia in the best delay time window. Methods SD rats were randomly divided into control group, MSCs group, MSCs + TCM group, each Section 10. intraluminal rats with ischemia-reperfusion model. MSCs injected into the tail vein group MSCs, MSCs + TCM group injected with Ginkgo biloba, Chuanxiong preparations, 48 h into the MSCs, the control group into the PBS. application of postural reflex test and asymmetric application of physical experiments neurological evaluation, brain tissue double immunofluorescence staining. Results MSCs group, MSCs + Medicines neurological level significantly better than the control group (P lt;0.05), the two treatment groups was no significant difference between the (Pgt; 0.05). Immunohistochemically, MSCs group, MSCs + Medicines infarct area in the expression of BDNF and GFAP were significantly. Effect of Ginkgo biloba, MSCs can Chuanxiong agents delay the treatment time window, and promote distribution of MSCs in the brain lesions, differentiation . [Keywords:] cerebral ischemia, Ginkgo biloba, Chuanxiong, bone marrow stromal cells Previous studies have confirmed that bone marrow stromal cells (MSCs) transplantation for treatment of cerebral venous ischemia efficacy does, can reduce infarct volume, and promote the recovery of neurological dysfunction (1), vein graft MSCs in the lack of optimal time window blood after 3 ~ 24 h, the optimal time window of clinical application of MSCs in treatment of focal cerebral ischemia can achieve the desired result. Chuanxiong active ingredients TMP and ferulic acid with the expansion of blood vessels, the role of platelet activity (2) active ingredient in ginkgo flavonoids and terpenes in lip