Hawthorn leaves flavonoids on cerebral ischemiareperfusion injury.docVIP

 PAGE \* MERGEFORMAT 13 Hawthorn leaves flavonoids on cerebral ischemiareperfusion injury Study: Real LI Ying Ji Shi-Jie Yang Qu polar ice [Abstract] Objective Hawthorn (FMCL on cerebral ischemia-reperfusion (CIR) injury and its possible mechanism. Methods intraluminal focal cerebral ischemia reperfusion injury model, its behavioral index score, TTC stain infarction, HE staining brain tissue pathological changes, transmission electron microscopy detected ultrastructural changes of neurons and brain tissue were detected superoxide dismutase (SOD activity and MDA (MDA and nitric oxide (NO content. Results FMCL nerve can significantly improve behavior, reduce infarct size, reduce the pathological changes of brain tissue and increase in brain tissue SOD activity and decrease in brain tissue MDA and NO content ( P lt;0.05 or P lt;0.01. Conclusion FMCL CIR reduce nerve cell injury, the mechanism may be related to anti-free radical damage, reduce the NO neurotoxicity. [Keywords:] Hawthorn, cerebral ischemia, cerebral infarction [Abstract] Objective To investigate the protective effects of flavone mixture of crataegus leaves (FMCLon cerebral ischemia reperfusion (CIR) injury in rats. Methods The CIR model was built through thread block. The neurologic deficit score and infarction area were measured. Then pathological change in injury brain tissue was detected by HE stain and transmission electron microscope. At the same time, the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) in brain tissue were observed. Results FMCL reduced cerebral infarction area , and relieved the injury of brain tissue. It also increased the activity of SOD and decreased the contents of MDA and NO in a dose dependent manner (P lt;0.05 or 0.01. Conclusions FMCL has a protective effect on CIR injury. Its mechanism maybe relate to anti radicals damage and lessen the neurotoxicity of NO. [Keywords:] FMCL, Cerebral ischemia reperfusion; Cerebral infar