Hematologic malignancies combined diagnosis and treatment of invasive fungal infection.docVIP

 PAGE \* MERGEFORMAT 20 Hematologic malignancies combined diagnosis and treatment of invasive fungal infection [Keywords:] diagnosis and treatment of fungal infection in hematologic malignancies In recent years, with the hematopoietic stem cell transplantation and enhanced technologies such as the widely used chemotherapy in hematologic malignancies and neutropenic patients, invasive fungal infections (invasive fungal infection, IFI) the incidence of the rise. IFI is the beginning of the disease a violation of deep tissues and organs, or lesions from local start further development of the violation of various organs, tissue formation Gan Ranzao, even give rise to fungal septicemia, is referred to as invasive or systemic invasive fungal infections. 30% of agranulocytosis can occur in patients with invasive fungal infections [1], case-fatality rate of up to 60%. In addition, with the fungal infection in hematology doctors emphasis and diagnostic technology continues to improve, more and more not previously considered in patients with fungal infections are now diagnosed as fungal infections, which makes a clear upward trend in fungal infection. Therefore, this article will be merged with hematologic malignancies diagnosis and treatment of invasive fungal infection in a comprehensive overview of the progress. A pathogen 1.1 Candida Candida is a condition of endogenous pathogenic bacteria, is a yeast-like genus, home of deep fungal infection in the first pathogen. Hematologic malignancies occurred in patients with invasive Candida infection risk factors include: central venous catheters, application of broad-spectrum antibiotics and corticosteroids, mucosal inflammation and long-term lack of neutrophils [2]. Common Candida infections are Candida albicans (50%), Candida tropicalis (25%), Candida glabrata (8%) and Candida parapsilosis (4%). But in recent years of non-Candida albicans caused by the deep mycoses accounted for more than 50% candidiasis, need to attr