Hepatic portal vein arterialization and portal shunt on liver regeneration.docVIP

 PAGE \* MERGEFORMAT 18 Hepatic portal vein arterialization and portal shunt on liver regeneration Study: Hsieh Yu Liu Qi Li Jian Guan Yan Cai Xiaodong Zhang Baimeng tidal farm [Abstract] [Objective] 70% partial hepatectomy in rats based on hepatic portal vein arterialization and portal shunt model and studied liver regeneration. [Method] 155 Sprague-Dawley rats were divided into 3 groups. 65 experimental rats, the use of right renal artery hepatic artery portal vein, parallel partial portacaval shunt and liver, liver cut group 65, only the partial hepatectomy control group, 25 , only the right kidney removed. and liver were observed in the experimental group cut 2,7,14 and 28 d postoperative remnant liver regeneration rate of change, and 3 patients in group 0 h, and 7 d after 24,48,72 h residues at each time point the proportion of liver cells in S phase and proliferating cell nuclear antigen (PCNA) positive cases of liver cell ratio. [Results] The mean rate of liver regeneration 2,7,14 d groups compared to the experimental group than in the liver cut significantly increased, the difference was statistically significant (P lt;0.01); to after 28 d, the experimental group and liver regeneration in liver cutting flattening ratio, the difference was not statistically significant (Pgt; 0.05). after each time point group of the experimental group and liver remnant liver cut S ratio of liver cells and liver cells in the proportion of PCNA expression was significantly higher than in the control group, the difference was statistically significant (P lt;0.01). cut the experimental group compared with the liver, remnant liver after 24 h the proportion of S phase cells and PCNA positive cells were already increased to 48,72 h after surgery and after 7 d, the experimental group was still significantly higher than that of the liver cut group, the difference was significant (P lt;0.01). [Conclusion] The hepatic portal vein arterialization on hepatic artery reconstructi