Helicobacter pylori resistance to clarithromycin Molecular Mechanism of.docVIP

 PAGE \* MERGEFORMAT 17 Helicobacter pylori resistance to clarithromycin Molecular Mechanism of [Abstract] Helicobacter pylori (Hpylori, Hp) is a chronic gastritis, peptic ulcer important factor. Research shows that, Hp and clear in favor of radical cure ulcers. And a direct impact on Hp Hp radical resistance and clear, Hp resistance to macrolides (clarithromycin) and their mechanism of V-23S rRNA mutations on the relevant area. With the annual increase rate of Hp resistance, the molecular mechanism of Hp and detection of resistance of technology to become hot spots. Therefore, to study Hp Hp resistance in the diagnosis and treatment of major significance. [Keywords:] Helicobacter pylori; drug resistance; clarithromycin; molecular mechanism Clarithromycin is a new generation of macrolide antibiotics, because of its stronger anti-Hp, and Hp eradication treatment as the main drug. But Hp over its resistance, the emergence of resistant strains led to eradication therapy major cause of failure [1-3]. China only recently began to use clarithromycin, Hp emergence of primary drug-resistant strains may be mainly concerned with the generic drug cross-resistance, treatment failure of about 1 / 2 to 2 / 3 of the strains acquired drug resistance can be their. Therefore, the resistance of Hp, resistance mechanisms and testing methods in clinical medicine and efficacy monitoring has become necessary. This article Hp resistance to clarithromycin reviewed. 1 Hp the resistance to clarithromycin With the widespread use of clarithromycin, Hp of resistant strains has increased gradually. Hp resistance to clarithromycin rates in different countries and regions has not been consistent. Kobayashi et al [4] found that Hp clarithromycin in Japan hormone resistance increased from 18.9% in 2002 to 27.7% in 2005, and there is significant gender differences (P lt;0.0001), male 19.2%, female 27.0%. They also found that the rate of clarithromycin resistance region differences.