HJD of atherosclerotic rat monocyte chemoattractant protein-1 and specific receptor expression of CCR2 mRNA.docVIP

 PAGE \* MERGEFORMAT 12 HJD of atherosclerotic rat monocyte chemoattractant protein-1 and specific receptor expression of CCR2 mRNA Of: Huang Ping, Kuo instrument, Li Guoqiang, Cheng Sui Ming, Luo Chengfeng, Liu Shiming [Abstract] [Objective] HJD of atherosclerosis (AS rat aortic monocyte chemoattractant protein 1 (MCP 1 and its specific receptor CCR2mRNA expression. [Method] The Big SD mice were randomly divided into normal control group, model group, HJD low, medium and high dose group (TCM group, the dose was 2.7,5.3,10.6 g kg-1 d-1, atorvastatin group ( dose of 1.8mg kg-1 d-1. In addition to the normal control group, other groups copy the AS model of high fat diet, 6 weeks of modeling administered for 4 weeks. obtained master rats in each group arteries using real-time fluorescent quantitative PCR method to detect the expression of MCP 1/CCR2mRNA. [results] and the normal control group, model group, the expression of aortic MCP 1/CCR2 mRNA was significantly higher (P lt;0.05 or P lt;0.01, with model group comparison, HJD each dose group MCP 1/CCR2 mRNA expression were significantly decreased (P lt;0.05 or P lt;0.01, and a dose-response relationship, MCP 1 and CCR2 expression was positively correlated between the two. [Conclusion] HJD treatment of the role of AS may be related to decreased MCP 1, CCR2 mRNA expression in the aorta. [Keywords:] HJD / pharmacology, Atherosclerosis / therapy, disease models, animal, rat Abstract: ObjectiveTo investigate the effect of Huanglian Jiedu Decoction (HJD on the expression of monocyte chemoattractant protein 1 (MCP 1 and its specific receptor CCR2 mRNA in rats with atherosclerosis (AS. MethodsSD rats were randomized into normal control group, model group, atorvastatin ( 1.8 mg kg-1 d-1 group, and low, moderate and high dosage HJD (in the dosages of 2.7,5.3 and 10.6 g kg-1 d-1, respectively groups. Rats except for the normal group were given high fat diet to induce AS. In the 6th week of modeling, the