Hormone therapy for postmenopausal women the impact of.docVIP

 PAGE \* MERGEFORMAT 13 Hormone therapy for postmenopausal women the impact of Keywords:: Sex hormones As the sex hormones in postmenopausal women in a wide range of applications and to carry out large-scale epidemiological studies, people of sex hormones on post-menopausal women, the beneficial effects and adverse effects of heated discussion. In this paper, an overview of recent literature. Review of sex hormones in postmenopausal women with osteoporosis, tumors, blood glucose control, heart, cerebrovascular diseases and senile dementia role. Found that sex hormones to control menopausal symptoms, preventing osteoporosis, fracture, etc., to reduce the beneficial effect has been confirmed, long-term use of sex hormones increase breast cancer, stroke and pulmonary embolism occurred in danger of reducing femoral neck fractures and colon cancer the risk of occurrence of blood glucose control appears to benefit, without increasing the risk of endometrial cancer, the incidence of coronary heart disease and overall mortality has not significantly affected. A sex hormone treatment on the role of osteoporosis The past, many experiments show that hormone treatment of osteoporosis prevention and improvement of the role, but the large-scale randomized controlled clinical study less information. Sweden Grodstein other studies have shown that oral administration of moderate doses of female hormone, or progesterone can decrease the risk of femoral neck fractures, risk (RR) were 0.65 [95% confidence interval (CI) 0.45 ~ 0 .95] and 0.6 (95% CI 0.41 ~ 1.00) [1]. The recently published ‘Women’s Health Initiative Study’ (WHI) is a large-scale multi-center randomized controlled study, the study included 16,608 cases of uterus in postmenopausal women who complete each day to give 0.625mg pregnant mother estrone and 2. 5mg medroxyprogesterone acetate (MPA) or placebo were followed up for 5.2 years, the results of hormone treatment group, RR = 0.66 femoral neck fractures [2]. An