Imidazoline antihypertensive drugs to study new advances.docVIP

 PAGE \* MERGEFORMAT 15 Imidazoline antihypertensive drugs to study new advances Is generally believed that the central antihypertensive drugs clonidine (clonidine) people are excited by the central α2 receptors and blood pressure. Discovered in the early 80s with the backbone of its antihypertensive effect of imidazoline receptor related, followed by a series of studies, particularly in recent years, many foreign research institutions, such as clonidine and moxonidine analogs (moxonidine) and Lee Kameni set (rilmenidine), were also a lot of research and made some progress. This paper made a brief introduction to its: 1 Clonidine and central imidazoline receptor Bousquet discovered in the early 80s such as the antihypertensive clonidine is not the central extension of the brain nucleus of solitary tract (NTS), while in the ventral medullary reticular nucleus (Nuleus Reiticularis Lateralis, NRL). NRL is about 1mm3, located in the mouth area ventrolateral medulla (rostral, ventrotaleral medulla, RVLM), the regulation of cardiovascular activity as important as the role of NTS. NRL, NTS negligible amount of local injection of clonidine, can be found to have significant step-down and no significant blood pressure difference. If the bilateral NRL damaged, the hypotensive effects of intravenous clonidine completely disappeared 〔1〕. To explore the NRL injection of antihypertensive effect of clonidine whether it is caused by the α2 receptor-mediated, Bousgnet other 〔2〕 many of the compounds will be injected into anesthetized cats NRL, such as α-methyl noradrenaline (α-MNE) (α2 by Body agonist), salad oxazoline (cirazoline) and ST587 (α receptor agonist), etc.. The results showed that, α-MNE does not cause the cat blood pressure and heart rate change, clonidine, salad oxazoline, ST587 can decrease blood pressure and heart rate slowed down slightly. Experiments with anesthetized rats also received the same result. From the chemical st