In rat kidney model of cervical spondylosis.docVIP

 PAGE \* MERGEFORMAT 10 In rat kidney model of cervical spondylosis [Abstract] The disease, the method permits model composite rat kidney deficiency animal model of cervical spondylosis. Methods: 3-month-old female SPF SD 30 rats were randomly divided into normal group, model group and kidney cervical spondylosis cervical spondylosis model for groups of 10 rats. Dynamic and static balance in rats with cervical disc degeneration model composite model of ovariectomized kidney deficiency Methods kidney model of cervical spondylosis. By detecting patterns in rat uterus and accessories and the quality of serum estradiol (estradiol, E2) content validation kidney deficiency syndrome; through the cervical intervertebral disc pathology, Ⅱ Ⅹ type and collagen immunohistochemical detection and Aggrecan ( aggrecan  1, Agc1), Ⅱ procollagen gene (type Ⅱ procollagen gene, Col2a1), matrix metalloproteinase  13 (matrix metalloproteinase  13, MMP  13) and matrix metalloproteinase inhibitor  1 (tissue inhibitor of metalloproteinases  1, TIMP  1) Evaluation of gene expression in intervertebral disc degeneration. Results: Compared with the normal group and model group, compared with cervical disease, kidney disease model animals type of cervical uterine contraction patterns and accessories, quality reduced, serum estradiol was reduced, cervical disc degeneration is more significant histopathology, Ⅱ collagen protein expression was decreased, Ⅹ increased expression of type I collagen, Agc1 and Col2a1 gene expression in lower, MMP  13 gene expression increased. Conclusion: The disease, card model compound approach to building a model of cervical spondylosis kidney deficiency, kidney deficiency can increase the cervical intervertebral disc degeneration. [Keywords:] Kidney Deficiency Syndrome of cervical spondylosis with animal disease model rats Objective: To establish a rat model of cervical syndrome (CS) with kidney deficiency. Methods: A group of 30 three